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KMID : 0545120040140051067
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Journal of Microbiology and Biotechnology
2004 Volume.14 No. 5 p.1067 ~ p.1070
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7-Oxostaurosporine Selectively Inhibits the Mycelial Form of Candida albicans
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Hwang EI
Yun BS/Lee SH/Kim SK/Lim SJ/Kim SU
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Abstract
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In the course of screening for specific inhibitors against the mycelial form of Candida albicans from natural resources we have isolated and identified A6792-1 from Streptomyces sp. A6792 by using several chromatographies. By spectral analyses this compound was determined as 7- oxostaurosporine having a structure of staurosporine aglycon moiety. 7-Oxostaurosporine exhibited a selective growth inhibitory activity against the mycelial form of Candida spp. up to 100 μg/disc in bioassay. It also exhibited a specific antifungal activity against the mycelial form of Candida spp. including C. krusei C. albicans C. tropicalis and C. lusitaniae with MICs ranging from 3.1 to 25 μg/ml. 7-Oxostaurosporine demonstrated no in vivo toxicity in SPF ICR mice. Therefore this compound may have a considerable potential as an antifungal agent based on the preferential inhibition against growth of the mycelial form of Candida spp. dimorphic fungi.
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